The Breast Unit is composed of four surgeons and receives about 4,400 new cases per year. Every week 45 surgeries are performed. 60% of the registrations are operable breast cancers, of which 70% are offered breast conservation surgery, and approximately 5% overall also undergo breast reconstruction. Sentinel node biopsy is offered only within studies and not as standard care. 35% of our cases are locally advanced cancers, all treated by multimodality treatment. 45% are offered BCT after NACT. The Unit also has many research protocols in various trial phases. Investigator-generated trials are appreciated and are focused on various clinical settings of operable breast cancer adjuvant treatment, neo-adjuvant in locally advanced breast cancer and the role of loco-regional treatment in primary metastatic breast cancer. There are also various Pharma-supported Phase I, Phase II and Phase III trials evaluating recent advances in chemotherapy, hormonal therapy and targeted therapies. Translational research is ongoing at the associated Research Center-ACTREC (Advanced Centre for Treatment, Research and Education in Cancer) at New Bombay (Navi Mumbai).